Clinical Trials

First Human

Clinical Trial NR

THERAPEUTIC GOODS ACT

 

LISTED COMPLIMENTARY MEDICINES

Complementary medicines (also known as 'traditional' or 'alternative' medicines) include vitamin, mineral, herbal, aromatherapy and homoeopathic products.

 

4 May 2018

To be a listed medicine on the Australian Register of Therapeutic Goods (ARTG) a product:read on

Complementary medicine regulation basics

NAD Deficiency, Congenital Malformations, and Niacin Supplementation Aug 10th 2017 read on 

 

Niacin, an old supplement with a new twist- read on

 

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. read on 

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. read on

Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease. read on

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. read on

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

read on 

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection read on

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults 

 

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD+ precursors to augment NAD+ bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD+ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD+metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.read on

Metabolic Roles of Niacin To fulfill its metabolic roles, niacin is initially incorporated into NAD+, which may be subsequently phosphorylated to form NAD(P)+, allowing enzyme selectivity (1). read on 

Clinical Trials and Niacin Pharmacological doses of nicotinic acid (1–3 g/d) reduce serum LDL cholesterol and increase serum HDL cholesterol, suggesting potential clinical benefits for the prevention and treatment of cardiovascular diseases (CVDs) (4). read on 

Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults read on 

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